The Nattokinase recommended by our association satisfies the following items and can be safely consumed.

1. Characteristics

   ・Producer Bacteria; Bacillus subtilis Natto
   ・Country of origin: Japan
   ・Standard: Vitamin K₂removed
2. Safety datas (in vitro and in vivo)

   ・Oral single dose toxicity study
   ・Oral 28-day repeated dose toxicity study
   ・Oral 90-day repeated dose toxicity study
   ・Reverse-mutation assay
   ・Chromosome Aberration Test
   ・Pathogenicity Test
3. Human Safety Study

   ・Nattokinase Supplementation with Warfarin
   ・Oral Nattokinase Supplement + Low Molecular Weight Heparin + Antiplatelet Drug (India)
   ・Nattokinase supplementation (2,000 FU /day), Double-blind, Parallel-group study (Japan)
   ・Nattokinase supplement (10,000 FU /day), Safety study
4. Use and management of non-GMO and non-animal ingredients
5. Certification

   ・U.S. FDA GRAS compliant
   ・EFSA Novel Food certification
   ・KFDA Health Claim for Functional Food
6. Third-party certification

   ・NSF GMP compliant
   ・FSSC22000 compliant
   ・Halal, Kosher compliant