We would like to express our deepest sympathies to all those who have been affected by the recent outbreak of the new coronavirus.

We have received numerous inquiries regarding the relationship between the new coronavirus, thrombosis, and Nattokinase.
We have decided that it is necessary to provide information on the relationship between the new coronavirus, thrombosis, and Nattokinase through our website, and we have decided to post only objective information on our website.

As already reported in TV programs and newspapers, respiratory symptoms such as fever and cough are the most frequent symptoms of new coronavirus infection, it may cause inflammation of blood vessels and thrombosis.
Especially in severe cases, thrombosis (deep vein thrombosis, pulmonary thromboembolism, cerebral infarction, myocardial infarction, and other arteriovenous thrombosis) occurs more frequently and is a cause of worsening systemic symptoms.
Although Nattokinase does not solve all of the symptoms of severe disease caused by this new coronavirus, we would like to introduce some of the findings related to Nattokinase that have been obtained so far as follows.

1. Inhibitory effect on infection of new coronavirus:
   In a study conducted by Tokyo University of Agriculture and Technology, it was confirmed that proteolytic enzymes in natto extract decompose the receptor binding region (spike) of the virus, thereby inhibiting infection of cultured cells with the new coronavirus.
   Oba. M. et al., 2021. Biochemical and Biophysical Research Communications Vol 570, 21-25
   
   
2. Immune function improving effect:
   It has been confirmed that a single intake of 4,000 FU of Nattokinase enhances the activity of NK cells (natural killer cells), which is an indicator of the immune function of the human body.
   Kurosawa. Y. et al., 2019. Japanese Pharmacology & Therapeutics 47(9), 1463-1469
   
   
3. Antithrombotic effect:
   It has been confirmed that a single dose of 2,000 FU of Nattokinase has enhanced the fibrinolytic system and inhibited the coagulation system.
   Kurosawa. Y. et al. 2015. Scientific Report 5: 11601.
   
   
4. Antithrombotic effect:
   Italian experts summarized health foods and nutritional supplements that may help prevent complications caused by COVID-19, and Nattokinase was introduced as one of them. In addition, the article 3. is cited in the report.
   ”Nutraceutical approach to preventing coronavirus disease 2019 and related complications” frotiers in Immunology.Retrieved from https://www.frontiersin.org/articles/10.3389/fimmu.2021.582556/full

We hope that this information will be useful to you and that the current situation will quickly improve.